Capitalizing on the inherent biodistribution of senescent RBCs into the liver and spleen, scientists at ERYTECH were the first to highlight the potential of antigen-loaded RBCs to modulate immune function by demonstrating both the induction of protein-specific tolerance, and the generation of antigen-specific immune response and subsequent tumor growth control in vivo (Cremel et al., Int J Pharm 2015; Banz et al., J Immunother 2012).

In June 2019, we entered into a partnership with SQZ Biotech to advance novel immune modulating RBC-based therapeutic candidates in which SQZ will combine its Cell Squeeze® cell engineering platform with Erytech’s significant IP and knowhow related to RBC-based therapeutics to develop novel immune modulating therapeutics addressing multiple indications.

SQZ intends to use platform to develop RBC-derived therapeutics to induce antigen-specific immune modulation for multiple disorders.

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